HP1 alpha Antibodies

Target Information

Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Note: This description may include information from UniProtKB.

Alternate Names

Antigen p25; CBX5; chromobox 5; chromobox homolog 5 (HP1 alpha homolog, Drosophila); Chromobox protein homolog 5; epididymis luminal protein 25; HEL25; Heterochromatin protein 1 homolog alpha; heterochromatin protein 1-alpha; HP1; HP1 alpha; HP1 alpha homolog; HP1-ALPHA; HP1A; HP1Hs alpha