IL33 Antibodies

Target Information

Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an alarmin, that amplifies immune responses during tissue injury. In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or proinflammatory activation. Belongs to the IL-1 family. Highly divergent. Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

9230117N10Rik; C9orf26; DKFZp586H0523; DVS27; DVS27-related protein; Il-; IL-1F11; IL-33; Il1f; IL1F11; Il1f11; IL33; Il33; interleukin 33; Interleukin-1 family member 11; Interleukin-33; Interleukin-33 (109-270); Interleukin-33 (95-270); Interleukin-33 (99-270); Interleukin-33(102-266); Interleukin-33(109-266); NF-H; NF-HEV; NFEHEV; NFHEV; nuclear factor for high endothelial venules; Nuclear factor from high endothelial venules; nuclear factor from high endothelial venules; RP11-575C20.2