JIP4 Antibodies

Target Information

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play a role in spermatozoa-egg-interaction. Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex. Belongs to the JIP scaffold family. Isoform 5 is expressed only in testis on the round spermatids of stage I, II and II. Isoform 5 is absent in spermatogonia and spermatocyte. Isoform 3 is expressed in testis. Isoform 4 is expressed in testis and in acute myeloid leukemia (AML) patients. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

c-Jun NH2-terminal kinase-associated leucine zipper protein; C-Jun-amino-terminal kinase-interacting protein 4; Cancer/testis antigen 89; CT89; FLJ13450; FLJ14006; FLJ26141; FLJ34602; HLC-4 protein; HLC-6; HLC4; HLC6; HSS; Human lung cancer oncogene 6 protein; JIP-4; JIP4; JLP; JNK interacting protein; JNK-associated leucine-zipper protein; JNK-interacting protein 4; JNK/SAPK-associated protein; KIAA0516; lung cancer oncogene 4; MAPK8IP4; Max-binding protein; MGC117291; MGC14967; MGC74461; Mitogen-activated protein kinase 8-interacting protein 4; PHET; PIG6; proliferation-inducing gene 6; Proliferation-inducing protein 6; Protein highly expressed in testis; SPAG9; sperm associated antigen 9; sperm associated antigen 9 variant 5; sperm specific protein; Sperm surface protein; Sperm-associated antigen 9; Sperm-specific protein; Sunday driver 1; SYD1