LGMN Antibodies

Target Information

Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Belongs to the peptidase C13 family. Ubiquitous. Particularly abundant in kidney, heart and placenta. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names