LRP1 Antibodies

Target Information

Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission. Acts as an alpha-2-macroglobulin receptor. (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A. Belongs to the LDLR family. Most abundant in liver, brain and lung. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

A2MR; Alpha-2-macroglobulin receptor; APOER; Apolipoprotein E receptor; APR; CD91; FLJ16451; IGFBP-3R; IGFBP3R; IGFBP3R1; KPA; LDL receptor related protein 1; low density lipoprotein receptor-related protein 1; Low-density lipoprotein receptor-related protein 1 515 kDa subunit; Low-density lipoprotein receptor-related protein 1 85 kDa subunit; Low-density lipoprotein receptor-related protein 1 intracellular domain; LRP; LRP-1; LRP-515; LRP-85; LRP1; LRP1A; LRPICD; MGC88725; Prolow-density lipoprotein receptor-related protein 1; TbetaR-V/LRP-1/IGFBP-3 receptor; TGFBR5; type V tgf-beta receptor