LRP6 Antibodies

Target Information

Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation. Belongs to the LDLR family. Widely coexpressed with LRP5 during embryogenesis and in adult tissues. Note: This description may include information from UniProtKB.

Alternate Names

ADCAD2; C030016K15Rik; Cd; crooked; FLJ90062; FLJ90421; LDL receptor related protein 6; low density lipoprotein receptor-related protein 6; low density lipoprotein-related protein 6; Low-density lipoprotein receptor-related protein 6; LRP-6; LRP6; Lrp6; OTTMUSP00000023469; ska; ska; ska26; skax; skax26; STHAG7