MTHFD1L Antibodies

Target Information

May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2. In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family. Detected in most tissues, highest expression found in placenta, thymus and brain. Low expression is found in liver and skeletal muscle. Up-regulated in colon adenocarcinoma. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

10-formyl-THF synthetase; C1TM; dJ292B18.2; DKFZp586G1517; FLJ21145; Formyltetrahydrofolate synthetase; formyltetrahydrofolate synthetase domain containing 1; FTHFSDC1; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like; mitochondrial C1-tetrahydrofolate synthase; mitochondrial C1-tetrahydrofolate synthetase; Monofunctional C1-tetrahydrofolate synthase, mitochondrial; MTC1THFS; MTHFD1L