NDRG4 Antibodies

Target Information

Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress. May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner. Belongs to the NDRG family. Expressed predominantly in brain and heart (at protein level). In the brain, detected in astrocytes. Isoform 1 and isoform 2 are only expressed in brain. Isoform 3 is expressed in both heart and brain. Up-regulated in glioblastoma multiforme cells. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

BDM1; Brain development-related molecule 1; DKFZp686I1615; FLJ30586; FLJ42011; KIAA1180; MGC19632; N-myc downstream-regulated gene 4 protein; NDRG family member 4; NDRG4; Protein NDRG4; SMAP-8; SMAP8; smooth muscle-associated protein 8; Vascular smooth muscle cell-associated protein 8