NFkB-p105 Antibodies

Target Information

a subunit of NF-kappa-B transcription complex (NFkB), which plays a crucial role in biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NFkB consists of homo- or heterodimeric complexes formed from the five NFkB proteins in mammals: RelA, RelB, c-REL, NFkB1, and NFkB2. They form a variety of homodimers and heterodimers, each binding at kappa-B sites in the DNA, regulating distinct sets of genes. Different dimer combinations act as transcriptional activators or repressors. NFkB1-p105 is processed into the shorter form NFkB1-p50 either cotranslationally or posttranslationally. p50/RelA and p50/RelB heterodimers are transcriptional activators. p50 homodimers are transcriptional repressor, but can act as a transcriptional activators when associated with BCL3. p50 binds to the kappa-B consensus sequence in enhancer region of genes involved in immune response and acute phase reactions. NFKB1-p105 binds Cot, inhibiting Cot-induced MAPK signaling; active Cot is released by proteasome-dependent degradation of p105. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

CVID12; DKFZp686C01211; DNA binding factor KBF1; DNA-binding factor KBF1; EBP-1; KBF1; MGC54151; NF kappaB1; NF-k; NF-kappa-B; NF-kappa-B1; NF-kappa-B1 p84/NF-kappa-B1 p98; NF-kappaB; NF-kappaB p50; NF-kappaB1; NF-kappabeta; NF-kB; NF-KB1; NF-kB1; NFkappaB; NFKB-p105; NFkB-p105; NFKB-p50; NFKB1; Nfkb1; NFKB1/p105; NFKB1/p50; nuclear factor kappa B subunit 1; nuclear factor kappa-B DNA binding subunit; nuclear factor kappaB p50; Nuclear factor NF-kappa-B p105 subunit; Nuclear factor NF-kappa-B p50 subunit; nuclear factor of kappa light chain gene enhancer in B-cells 1, p105; nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105; nuclear factor-kappaB p50; OTTMUSP00000018024; p105; p50; p50 subunit of NF kappaB; p50 subunit of NF-kappaB; p50/p1; p50/p105