NOTCH3 Antibodies
Target Information
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Belongs to the NOTCH family. Ubiquitously expressed in fetal and adult tissues. Note: This description may include information from UniProtKB.
Alternate Names
CADASIL; CADASIL1; CASIL; IMF2; LMNS; Neurogenic locus notch homolog protein 3; NOTC3; Notch 3; Notch 3 extracellular truncation; Notch 3 intracellular domain; Notch homolog 3; Notch homolog 3 (Drosophila); notch receptor 3; NOTCH3NOTCH3 Antibody Products
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