PAPSS1 Antibodies

Target Information

a bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells. The N-terminal section belongs to the adenylyl-sulfate kinase (APS) family. The C-terminal section belongs to the sulfate adenylyltransferase family. The N-terminal first 50 residues are required for inhibition by the substrate adenylyl sulfate. Expressed in testis, pancreas, kidney, thymus, prostate, ovary, small intestine, colon, leukocytes and liver. Also expressed in high endothelial venules (HEV) cells and in cartilage. Note: This description may include information from UniProtKB.

Alternate Names

3-prime-phosphoadenosine 5-prime-phosphosulfate synthase 1; 3'-phosphoadenosine 5'-phosphosulfate synthase 1; 3'-phosphoadenosine-5'-phosphosulfate synthase; Adenosine-5'-phosphosulfate 3'-phosphotransferase; Adenylyl-sulfate kinase; Adenylylsulfate 3'-phosphotransferase; APS kinase; ATP-sulfurylase; ATPSK1; Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1; PAPS synthase 1; PAPS1; PAPSS; PAPSS 1; PAPSS1; SAT; SK 1; SK1; Sulfate adenylate transferase; Sulfate adenylyltransferase; Sulfurylase kinase 1