PIP4K2C Antibodies

Target Information

Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3. Interacts with PIP5K1A; the interaction inhibits PIP5K1A kinase activity. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

FLJ22055; phosphatidylinositol 4-phosphate 5-kinase; Phosphatidylinositol 5-phosphate 4-kinase type II gamma; Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma; phosphatidylinositol-4-phosphate 5-kinase, type II, gamma; phosphatidylinositol-5-phosphate 4-kinase type 2 gamma; Phosphatidylinositol-5-phosphate 4-kinase type II gamma; Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma; phosphatidylinositol-5-phosphate 4-kinase, type II, gamma; PI(5)P 4-kinase type II gamma; PI42C; PIP4K2C; PIP4KII-gamma; PIP5K2C