PSENEN Antibodies

Target Information

Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity. Belongs to the PEN-2 family. Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain. Note: This description may include information from UniProtKB.

Alternate Names

ACNINV2; Gamma-secretase subunit PEN-2; hematopoietic stem/progenitor cells protein MDS033; MDS033; MSTP064; PEN-2; PEN2; presenilin enhancer 2 homolog; presenilin enhancer 2 homolog (C. elegans); Presenilin enhancer protein 2; presenilin enhancer, gamma-secretase subunit; PSENEN