RALA Antibodies

Target Information

Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells. During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody. Belongs to the small GTPase superfamily. Ras family. Note: This description may include information from UniProtKB.

Alternate Names

MGC48949; RAL; RALA; RALA Ras like proto-oncogene A; Ras family small GTP binding protein RALA; RAS like proto-oncogene A; ras related GTP binding protein A; ras related v-ral simian leukemia viral oncogene homolog A; RAS-like protein A; Ras-related protein Ral-A; v-ral simian leukemia viral oncogene homolog A (ras related)