SEC61A1 Antibodies

Target Information

Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins. Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC61 channel, contributing to the maintenance of cellular calcium homeostasis. Plays a critical role in nephrogenesis, specifically at pronephros stage. Belongs to the SecY/SEC61-alpha family. Expressed in proximal and distal tubules in kidney (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

HNFJ4; HSEC61; protein transport protein SEC61 alpha subunit; protein transport protein Sec61 subunit alpha; Protein transport protein Sec61 subunit alpha isoform 1; S61A1; SEC61; Sec61 alpha 1 subunit; Sec61 alpha 1 subunit (S. cerevisiae); Sec61 alpha-1; sec61 homolog; SEC61 translocon alpha 1 subunit; SEC61 translocon subunit alpha 1; SEC61A; SEC61A1