SOCS1 Antibodies

Target Information

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway. Belongs to the SOCS1 family. Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes. Note: This description may include information from UniProtKB.

Alternate Names

CIS1; CISH1; cytokine-inducible SH2 protein 1; JAB; JAK binding protein; JAK-binding protein; SOCS-1; SOCS1; SSI-1; SSI1; STAT induced SH3 protein 1; STAT-induced STAT inhibitor 1; Suppressor of cytokine signaling 1; Tec-interacting protein 3; TIP-3; TIP3