Syk Antibodies

Target Information

a cytoplasmic tyrosine kinase of the SYK family containing two SH2 domains. Mediates signal transduction downstream of the B-cell antigen receptor (BCR) as well as a variety of other transmembrane receptors. Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM and partial hemITAM domains. Direct downstream effectors phosphorylated by SYK include VAV1, PLCG, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition. Plays a role in T-cell receptor signaling and in the innate immune response to fungal, bacterial and viral pathogens. Activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade. Required for the stimulation of neutrophil phagocytosis by IL15. Involved in the activation of dendritic cells by cell necrosis stimuli, and in mast cells activation. Involved in interleukin-3/IL3-mediated signaling pathway in basophils. Functions downstream of receptors mediating cell adhesion. Is involved in vascular development where it may regulate blood and lymphatic vascular separation. Required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. Activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen. Together with CEACAM20, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response. Expression highest in murine spleen, heart, mammary gland and thymus. Widely expressed in hematopoietic cells. Expressed in neutrophils. Within the B-cell compartment, expressed from pro- and pre-B cells to plasma cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names