TNF-R1 Antibodies

Target Information

Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

CD120; CD120a; FPF; MGC19588; OTTMUSP00000028139; p55; p55-R; p60; TBP1; TBPI; Tnf; TNF receptor alpha chain; TNF receptor superfamily member 1A; TNF-; TNF-a; TNF-alpha-R1; TNF-alphaR1; TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNF-RI; TNFal; TNFalpha-R1; TNFAR; TNFR; Tnfr-1; Tnfr-2; TNFR-I; TNFR1; Tnfr1; TNFR55; TNFR60; TNFRI; TNFRp55; TNFRSF1A; Tnfrsf1a; TNR1A; tumor necrosis factor binding protein 1; Tumor necrosis factor receptor 1; tumor necrosis factor receptor 1A isoform beta; Tumor necrosis factor receptor superfamily member 1A; Tumor necrosis factor receptor superfamily member 1A, membrane form; tumor necrosis factor receptor superfamily, member 1A; tumor necrosis factor receptor superfamily, member 1a; tumor necrosis factor receptor type 1; Tumor necrosis factor receptor type I; tumor necrosis factor-alpha receptor; Tumor necrosis factor-binding protein 1