Tau Antibodies

Target Information

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system. 9 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

AI413597; AW045860; DDPAC; FLJ31424; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; MAPT; Mapt; MAPTL; MGC138549; microtubule associated protein tau; Microtubule-associated protein tau; MSTD; Mta; Mtapt; MTBT1; MTBT2; Neurofibrillary tangle protein; OTTMUSP00000003078; OTTMUSP00000003083; Paired helical filament-tau; PHF-tau; PPND; PPP1R103; protein phosphatase 1, regulatory subunit 103; TAU; Tau; Tau iso2; Tau iso4; Tau iso5; Tau iso6; Tau iso7; Tau iso8; Tau isoform Tau-E