VISTA Antibodies

Target Information

Immunoregulatory receptor which inhibits the T-cell response. May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling. May stimulate MMP14-mediated MMP2 activation. Expressed in spleen. Detected on a number of myeloid cells including CD11b monocytes, CD66b+ neutrophils, at low levels on CD4+ and CD8+ T-cells, and in a subset of NK cells. Not detected on B cells (at protein level). Expressed at high levels in placenta, spleen, plasma blood leukocytes, and lung. Expressed at moderate levels in lymph node, bone marrow, fat, uterus, and trachea. Has low expression levels in other tissues. Note: This description may include information from UniProtKB.

Alternate Names

4632428N05Rik; B7-H5; B7H5; C10orf54; DD1alpha; Death Domain1alpha; Die; Dies1; differentiation of ESCs 1; GI24; Gi24 receptor; PD-1; PD-1H; PDCD1 homolog; Platelet receptor Gi24; PP2135; Sisp-1; SISP1; stress induced secreted protein 1; Stress-induced secreted protein-1; V-domain Ig suppressor of T cell activation; V-set domain-containing immunoregulatory receptor; V-set immunoregulatory receptor; V-type immunoglobulin domain-containing suppressor of T-cell activation; VISTA; VSIR; Vsir