Akt2 Antibodies

Target Information

one of three AKT kinases of the AGC family which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. AKT2 plays critical roles in the regulation of glucose uptake and the development or maintenance of proper adipose tissue and islet mass for which other Akt paralogs are unable to fully compensate. Specifically involved in skeletal muscle differentiation. Amplified and overexpressed in human ovarian carcinoma cell lines and amplified in some primary ovarian and pancreatic tumors. Antisense blocks invasiveness in xenografts. Expressed in several insulin-responsive tissues, and one case of Type II diabetes has been associated with a likely LOF point mutation. Mouse mutants have defects in insulin response. Two alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

2410016A19Rik; akt 2; AKT serine/threonine kinase 2; AKT2; Akt2; AW554154; HIHGHH; MGC14031; Murine thymoma viral (v-akt) homolog-2; OTTMUSP00000017783; OTTMUSP00000017784; OTTMUSP00000017785; PKB; PKB beta; PKBB; PKBbe; PKBBETA; PKBbeta; PRKBB; Protein kinase Akt-2; Protein kinase B beta; protein kinase B, beta; putative v-akt murine thymoma viral oncoprotein 2; rac protein kinase beta; RAC-BETA; RAC-beta serine/threonine protein kinase; RAC-beta serine/threonine-protein kinase; RAC-PK-beta; thymoma viral proto-oncogene 2; v-akt murine thymoma viral oncogene homolog 2