Akt Antibodies

Target Information

an oncogenic AGC kinase that plays a critical role in regulating many processes including cell survival, metabolism, proliferation, growth and angiogenesis. Over 160 protein substrates are known including many that regulate transcription, metabolism, apoptosis, cell cycle, and growth. The activation of phosphatidylinositol 3-kinase alpha (PIK3CA) at the plasma membrane generates phosphatidylinositol 3,4,5-trisphosphate (PIP3), which binds to the PH domain of Akt, inducing its translocation to the plasma membrane. Dual phosphorylation is required for its activation. T308 is phosphorylated by PDK1 in the PI3 kinase pathway, and S473 is phosphorylated by mTOR in the mTORC2 pathway. The 'Lys-63'-linked ubiquitination of AKT1 by TRAF6 is important for its translocation to the plasma membrane, phosphorylation, and activation. When Akt is fully phosphorylated it translocates into the nucleus, undergoes 'Lys-48'-polyubiquitination catalyzed by TTC3, leading to its proteosomal degradation. Hyperactive or overexpressed in a number of cancers including breast, prostate, lung, pancreatic, liver, ovarian and colorectal. Two alternatively-spliced human isoforms have been described. Note: This description may include information from UniProtKB.

Alternate Names

AKT; Akt; AKT serine/threonine kinase 1; Akt-PA; Akt-PB; Akt-PC; Akt-PD; Akt-PE; AKT1; Akt1; AKT1 kinase; AKT1m; Akt1m protein; D-Akt; dAkt kinase; dAKT1; LTR-akt; MGC99656; OTTMUSP00000022944; OTTMUSP00000022949; PKB; PKB alpha; PKB-ALPHA; PKB/A; PKB/Akt; PKBalpha; PRKBA; Protein kinase B; protein kinase B; Protein kinase B alpha; protein kinase B-alpha; Proto-oncogene c-Akt; RAC; Rac; rac protein kinase alpha; RAC serine/threonine-protein kinase; RAC-ALPHA; RAC-alpha serine/threonine-protein kinase; RAC-PK-alpha; related to A and C kinases; related to PKA to PKC protein kinases; related to the A and C kinases; serine-threonine protein kinase; Thymoma viral proto-oncogene; thymoma viral proto-oncogene 1; tumor rejection antigen peptide pRLib; v-akt murine thymoma viral oncogene homolog 1; v-akt murine thymoma viral oncogene-like protein 1