APOBEC3A Antibodies

Target Information

a single-stranded DNA cytidine deaminase involved in foreign DNA clearance with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic C-to-U hypermutation in nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. Interacts with AGO2. Interacts with TRIB3. Expressed in peripheral leukocytes with higher expression in CD14-positive phagocytic cells. Highly expressed in keratinocytes and in periphery blood monocytes. Also detected in non-lymphoid tissues including lung and adipose tissues. Found at high levels in colorectal adenocarcinoma, Burkitt's lymphoma and chronic myelogenous leukemia. Up-regulated by interferon and CpG single-stranded DNA (at protein level). Belongs to the cytidine and deoxycytidylate deaminase family. 2 isoforms of the human protein are produced by alternative initiation. Note: This description may include information from UniProtKB.

Alternate Names

A3A; ABC3A; APOBEC3A; apolipoprotein B mRNA editing enzyme catalytic subunit 3A; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A; ARP3; bK150C2.1; DNA dC->dU-editing enzyme APOBEC-3A; phorbolin 1; Phorbolin-1; PHRBN; Probable DNA dC->dU-editing enzyme APOBEC-3A