ATG12 Antibodies

Target Information

Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. (Microbial infection) May act as a proviral factor. In association with ATG5, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection. Required for the translation of incoming hepatitis C virus (HCV) RNA and, thereby, for the initiation of HCV replication, but not required once infection is established. Belongs to the ATG12 family. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

4931423H11Rik; A330058M13Rik; Apg; APG12; Apg12; Apg12 (autophagy, yeast) homolog; APG12 autophagy 12-like; APG12-like; APG12L; Apg12l; ATG12; Atg12; ATG12 autophagy related 12 homolog; ATG12 autophagy related 12 homolog (S. cerevisiae); Atg12l; autophagy 12-like; autophagy related 12; autophagy-related 12 (yeast); autophagy-related 12-like; Autophagy-related protein 12; FBR93; HAPG12; Ubiquitin-like protein ATG12