ATG16L1 Antibodies

Target Information

Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane. Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production. Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response. Instead, promotes with NOD2 an autophagy-dependent antibacterial pathway. Plays a role in regulating morphology and function of Paneth cell. Belongs to the WD repeat ATG16 family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

A16L1; APG16 autophagy 16-like; APG16-like 1; APG16L; APG16L beta; ATG16; ATG16 autophagy related 16-like 1; ATG16 autophagy related 16-like 1 (S. cerevisiae); ATG16 autophagy related 16-like protein 1; ATG16A; ATG16L; ATG16L1; autophagy related 16 like 1; Autophagy-related protein 16-1; FLJ00045; FLJ10035; FLJ10828; FLJ22677; IBD10; WD repeat domain 30; WDR30