ATG4B Antibodies

Target Information

Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms. Belongs to the peptidase C54 family. Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

APG4 autophagy 4 homolog B; APG4B; ATG4 autophagy related 4 homolog B; ATG4 autophagy related 4 homolog B (S. cerevisiae); ATG4B; AUT-like 1 cysteine endopeptidase; AUTL1; Autophagin-1; autophagy related 4B cysteine peptidase; Autophagy-related cysteine endopeptidase 1; Autophagy-related protein 4 homolog B; Cysteine protease ATG4B; hAPG4B; KIAA0943; MGC1353