BAF Antibodies

Target Information

Plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. May potently compress chromatin structure and be involved in membrane recruitment and chromatin decondensation during nuclear assembly. Contains 2 non-specific dsDNA-binding sites which may promote DNA cross-bridging. (Microbial infection) Exploited by retroviruses for inhibiting self-destructing autointegration of retroviral DNA, thereby promoting integration of viral DNA into the host chromosome. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. (Microbial infection) In case of poxvirus infection, has an antiviral activity by blocking viral DNA replication. Belongs to the BAF family. Widely expressed. Expressed in colon, brain, heart, kidney, liver, lung, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen and testis. Not detected in thymus and peripheral blood leukocytes. Note: This description may include information from UniProtKB.

Alternate Names

BAF; BAF nuclear assembly factor 1; BANF1; barrier to autointegration factor 1; Barrier-to-autointegration factor; Barrier-to-autointegration factor, N-terminally processed; BCRG1; BCRP1; Breakpoint cluster region protein 1; D14S1460; MGC111161; NGPS