CAPN2 Antibodies

Target Information

Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs. Belongs to the peptidase C2 family. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

Calcium-activated neutral proteinase 2; Calpain 2; calpain 2, (m/II) large subunit; calpain 2, large [catalytic] subunit; calpain 2, large subunit; Calpain large polypeptide L2; Calpain M-type; Calpain-2; Calpain-2 catalytic subunit; Calpain-2 large subunit; calpain, large polypeptide L2; CAN2; CANP 2; CANP2; CANPL2; CANPml; CAPN2; FLJ39928; M-calpain; mCANP; Millimolar-calpain