dectin-1 Antibodies

Target Information

Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta. 10 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

beta-; Beta-glucan receptor; beta-GR; BGR; Bgr; C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12; C-type lectin domain containing 7A; C-type lectin domain family 7 member A; C-type lectin domain family 7, member A; C-type lectin domain family 7, member a; C-type lectin superfamily member 12; CANDF4; CD369; CLC7A; CLEC7A; Clec7a; Clecsf; CLECSF12; Clecsf12; DC-associated C-type lectin 1; dectin; Dectin-1; DECTIN1; Dectin1; Dendritic cell-associated C-type lectin 1; dendritic cell-associated C-type lectin-1; lectin-like receptor 1; SCARE2