EphB2 Antibodies

Target Information

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Brain, heart, lung, kidney, placenta, pancreas, liver and skeletal muscle. Preferentially expressed in fetal brain. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

BDPLT22; CAPB; Developmentally-regulated Eph-related tyrosine kinase; DRT; EK5; elk-related tyrosine kinase; EPH receptor B2; eph tyrosine kinase 3; EPH-like kinase 5; EPHB2; EphB2/CTF1; EphB2/CTF2; Ephrin type-B receptor 2; EPHT3; EPTH3; ERK; HEK5; MGC87492; PCBC; protein-tyrosine kinase HEK5; Renal carcinoma antigen NY-REN-47; TYRO5; Tyrosine-protein kinase receptor EPH-3; Tyrosine-protein kinase TYRO5