FCGR2B Antibodies

Target Information

Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis. Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

AI528646; CD32; CD32B; CDw32; F630109E10Rik; Fc fragment of IgG receptor IIb; Fc fragment of IgG, low affinity II, receptor for (CD32); Fc fragment of IgG, low affinity IIb, receptor (CD32); Fc fragment of IgG, low affinity IIb, receptor for (CD32); Fc gamma receptor IIB; Fc gamma receptor IIb; Fc gamma RIIB; Fc gamma RIIb; Fc receptor, IgG, low affinity IIb; Fc-gamma RII; Fc-gamma RII-b; Fc-gamma RII-c; Fc-gamma-RII; Fc-gamma-RIIB; Fc-gamma-RIIb; Fc-gamma-RIIc; Fc[g]; Fc[g]RII; Fcg; FCG2; FCG2B; Fcgamm; FcgammaRIIB; Fcgr; FCGR2; Fcgr2; Fcgr2a; FCGR2B; Fcgr2b; FCGR2B iso2; FCGR2C; FcgRII; Fcr-; Fcr-2; Fcr-3; FcRII; FcRII-b; FcRII-c; IGFR2; IgG Fc receptor II beta; IgG Fc receptor II-b; IgG Fc receptor II-c; Low affinity immunoglobulin gamma Fc region receptor II; Low affinity immunoglobulin gamma Fc region receptor II-b; low affinity immunoglobulin gamma Fc region receptor II-b; Low affinity immunoglobulin gamma Fc region receptor II-c; Ly-1; Ly-17; Ly-m2; Ly-m20; LyM-; LyM-1; Lymphocyte antigen 17; OTTMUSP00000024374; OTTMUSP00000024375