FOXA2 Antibodies

Target Information

Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3'. In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

forkhead box A2; Forkhead box protein A2; FOXA2; Foxa2; hepatic nuclear factor-3-beta; hepatocyte nuclear factor 3 beta (winged helix transcription factor); Hepatocyte nuclear factor 3-beta; hepatocyte nuclear factor 3, beta; hepatocyte nuclear factor-3 beta; Hnf-3; HNF-3-beta; HNF-3B; Hnf3; HNF3-be; HNF3-beta; HNF3B; Hnf3b; HNF3be; HNF3beta; MGC19807; OTTMUSP00000016693; OTTMUSP00000016694; TCF-3B; Tcf-3b; TCF3B; Tcf3b; Transcription factor 3B