HDGF2 Antibodies

Target Information

Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters. Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs. Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2. Involved in cellular growth control, through the regulation of cyclin D1 expression. Interacts with HDGF. Interacts with trimethylated 'Lys-36' of histone H3 (H3K36me3). Interacts with trimethylated 'Lys-79' of histone H3 (H3K79me3), but has higher affinity for H3K36me3. Interacts with IWS1. Interacts with H2AX, POGZ, RBBP8 and CBX1. Interacts with histones H3K9me3, H3K27me3 and H3K36me2. Interacts with DPF3a (isoform 2 of DPF3/BAF45C). Interacts with SMARCA4/BRG1/BAF190A, SMARCC1/BAF155 and SMARCD1/BAF60A in a DPF3a-dependent manner. Interacts with MPHOSPH8. Overexpression is frequently observed in hepatocellular carcinoma samples. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names