HEXIM1 Antibodies

Target Information

Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Belongs to the HEXIM family. Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues. Note: This description may include information from UniProtKB.

Alternate Names

Cardiac lineage protein 1; CLP1; EDG1; Estrogen down-regulated gene 1 protein; FLJ13562; hexamethylene bis-acetamide inducible 1; Hexamethylene bis-acetamide-inducible protein 1; hexamethylene bisacetamide inducible 1; hexamethylene bisacetamide-inducible protein; hexamethylene-bis-acetamide-inducible transcript 1; hexamthylene bis-acetamide inducible 1; HEXI1; HEXIM P-TEFb complex subunit 1; HEXIM1; HIS1; HMBA-inducible; MAQ1; menage a quatre 1; Menage a quatre protein 1; Protein HEXIM1