ICOS Antibodies

Target Information

Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes. Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B-cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

Activation-inducible lymphocyte immunomediatory molecule; AILIM; Ailim; CCLP; CD278; CD28 and CTLA-4-like protein; CD28-related protein 1; CH29-120A16.4; CRP-1; CVID1; ICOS; inducible costimulator; inducible T cell co-stimulator; inducible T cell costimulator; inducible T-cell co-stimulator; Inducible T-cell costimulator; Ly115; MGC39850; OTTHUMP00000163785; OTTHUMP00000208080; OTTMUSP00000002206; OTTMUSP00000002207