IFITM2 Antibodies

Target Information

IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. Belongs to the CD225/Dispanin family. Note: This description may include information from UniProtKB.

Alternate Names

1-8D; Dispanin subfamily A member 2c; DSPA2c; fra; Fragilis protein 3; Fragilis R; fragilis3; Ifit; IFITM2; Ifitm2; Ifitm2 protein; Ifitm3l; IFM2; Interferon induced transmembrane protein 2; interferon induced transmembrane protein 2; interferon induced transmembrane protein 2 (1-8D); interferon induced transmembrane protein 3-like; interferon induced transmembrane protein, like; Interferon-induced transmembrane protein 2; Interferon-inducible protein 1-8D; MCG22584; MGC102396; mil; mil-3