INPP4B Antibodies

Target Information

Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate. Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles. The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. Belongs to the inositol 3,4-bisphosphate 4-phosphatase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

4-phosphatase II; inositol polyphosphate 4-phosphatase II; Inositol polyphosphate 4-phosphatase type II; inositol polyphosphate-4-phosphatase type II B; inositol polyphosphate-4-phosphatase, type II, 105kDa; INP4B; INPP4B; MGC132014; Type II inositol 3,4-bisphosphate 4-phosphatase; Type II inositol-3,4-bisphosphate 4-phosphatase