KEAP1 Antibodies

Target Information

Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome. Broadly expressed, with highest levels in skeletal muscle. Note: This description may include information from UniProtKB.

Alternate Names

Cytosolic inhibitor of Nrf2; INRF2; KEAP1; KEAP1 delta C; kelch like ECH associated protein 1; Kelch-like ECH-associated protein 1; kelch-like family member 19; Kelch-like protein 19; KIAA0132; KLHL19; MGC10630; MGC1114; MGC20887; MGC4407; MGC9454