LAMTOR1 Antibodies

Target Information

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation. Belongs to the LAMTOR1 family. Note: This description may include information from UniProtKB.

Alternate Names

C11orf59; chromosome 11 open reading frame 59; CK059; FLJ20625; LAMTOR1; Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1; late endosomal/lysosomal adaptor, MAPK and MTOR activator 1; Lipid raft adaptor protein p18; LTOR1; p18; p27kip1 releasing factor from RhoA; p27Kip1-releasing factor from RhoA; p27RF-Rho; PDRO; Protein associated with DRMs and endosomes; Ragulator complex protein LAMTOR1; ragulator complex protein PDRO; Ragulator1; RhoA activator C11orf59