NFkB-p100 Antibodies

Target Information

a subunit of NF-kappa-B transcription complex (NFkB), which plays a crucial role in biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NFkB consists of homo- or heterodimeric complexes formed from the five NFkB proteins in mammals: RelA, RelB, c-REL, NFkB1, and NFkB2. They form a variety of homodimers and heterodimers, each binding at kappa-B sites in the DNA, regulating distinct sets of genes. Different dimer combinations act as transcriptional activators or repressors. In a non-canonical activation pathway, the Nik-activated IKKA homodimer phosphorylates NFKB2-p100 associated with RelB, inducing its proteolytic processing to NFKB2-p52 and the formation of RelB/p52 complexes. The heterodimeric RelB/p52 complex is a transcriptional activator while the p52/p52 homodimer is a transcriptional repressor. NFKB2-p52 regulates the transcription of genes involved in immune response and acute phase reactions. Isoform 3 is a subunit of the NFkB protein complex that binds the HIV enhancer. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK/BMAL1 heterodimer. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

CVID10; DNA-binding factor KBF2; H2TF1; Lymphocyte translocation chromosome 10 protein; lyt; LYT-10; LYT10; NF kappaB2; NF-kappaB2; NF-kB2; NFkB-p100; NFKB, p52/p100 subunit; NFKB2; Nfkb2; NFKB2/p52; nuclear factor kappa B subunit 2; nuclear factor Kappa-B, subunit 2; Nuclear factor NF-kappa-B p100 subunit; Nuclear factor NF-kappa-B p52 subunit; nuclear factor of Kappa light chain gene enhancer in B cells 2; nuclear factor of kappa light chain gene enhancer in B-cells 2; nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100); nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100; Oncogene Lyt-10; p100; p49; p49/p100; p50B; p52; transcription factor NFKB2