NR1D1 Antibodies

Target Information

a widely expressed member of the nuclear hormone receptor family of proteins. Transcriptional repressor which influence circadian rhythms, inflammatory responses and metabolic pathways in a heme-dependent manner. Lacks the activation function 2 domain required for ligand-dependent activation of transcription by other members of the nuclear receptor family; thus it behaves as a constitutive repressor protein, recruiting the nuclear receptor co-repressor N-CoR1/HDAC3 complex to target genes to repress transcription. Heme binding stimulates its interaction with the NCOR1/HDAC3 corepressor complex. Acts as a potent competitive repressor of ROR alpha (RORA) function and regulates the levels of its ligand heme by repressing the expression of PPARGC1A, a potent inducer of heme synthesis. Regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Influences gluconeogenesis via repression of G6PC and PEPCK and adipocyte differentiation via repression of PPARG. Regulates malate dehydrogenase 1 (MDH1) and malic enzyme 1 (ME1), enzymes that link glycolysis and fatty acid synthesis. Its expression is increased in HER2-positive breast cancer cells, and may contribute to the abnormal cellular energy metabolism observed in HER2-positive breast cancers. Regulates inflammation by inhibiting the expression of Il17a and Il17f in TH17 cells, repressing the expression of inflammatory cytokines and chemokines in macrophages, and by targeting the NF-KB responsive genes IL-6 and COX-2. Elevated expression inhibits the progression of experimental autoimmune encephalomyelitis (EAE). Under resting, non-stress conditions, acts as a rhythmic repressor to limit inflammatory activity. However, inflammation triggers its ubiquitin-mediated degradation thereby relieving inhibition of the inflammatory response. Its expression increases during differentiation in adipocytes and its ectopic expression in 3T3-L1 cells potentiates adipocyte differentiation. Its expression oscillates with circadian rhythm in liver cells, regulating the expression of BMAL1, ApoA1 and ApoC3, all key regulators of circadian rhythm. Represses the basal activity of the mouse Bmal1 gene promoter. Plays a key role in the circadian regulation of microglial activation and neuroinflammation; suppresses microglial activation through the NF-kappaB pathway in the central nervous system. Plays a role in the regulation of the diurnal rhythms of lipid and protein metabolism in the skeletal muscle via transcriptional repression of genes controlling lipid and amino acid metabolism in the muscle. Expression oscillates diurnally in the suprachiasmatic nucleus (SCN) of the hypothalamus as well as in peripheral tissues. In addition to its activity as a repressor, can also act as a transcriptional activator. In the ovarian granulosa cells acts as a transcriptional activator of STAR which plays a role in steroid biosynthesis. In collaboration with SP1, activates GJA1 transcription in a heme-independent manner. Expressed at high levels in the liver, adipose tissue, skeletal muscle and brain. Also expressed in endothelial cells (ECs), vascular smooth muscle cells (VSMCs) and macrophages. Expressed at high levels in some squamous carcinoma cell lines. Belongs to the NR1 subfamily of nuclear receptors. Note: This description may include information from UniProtKB.

Alternate Names

EAR-1; EAR1; HREV; NR1D1; nuclear receptor Rev-ErbA-alpha; Nuclear receptor subfamily 1 group D member 1; nuclear receptor subfamily 1, group D, member 1; Rev-erbA-alpha; Rev-ErbAalpha; REVERBA; REVERBalpha; THRA1; THRAL; thyroid hormone receptor, alpha-like; V-erbA-related protein 1