p16-INK4A Antibodies

Target Information

Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. Belongs to the CDKN2 cyclin-dependent kinase inhibitor family. Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

alternative reading frame; ARF; Arf; ARF-; ARF-INK4a; CD2A1; CDK4 inhibitor p16-INK4; CDK4I; CDKN2; CDKN2A; Cdkn2a; CDN2A; cell cycle negative regulator beta; CMM2; cyclin dependent kinase inhibitor 2A; Cyclin-dependent kinase 4 inhibitor A; Cyclin-dependent kinase inhibitor 2A; cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2A (p16, inhibits CDK4); cyclin-dependent kinase inhibitor 2A, isoform 3; cyclin-dependent kinase inhibitor 2A, isoform 4; Cyclin-dependent kinase inhibitor 2A, isoforms 1/2; Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3; cyclin-dependent kinase inhibitor p16; cyclin-dependent kinase inhibitor protein; INK4; INK4a; INK4a-ARF; Ink4a/Arf; mitochondrial smARF; MLM; MTS; MTS-1; MTS1; Multiple tumor suppressor 1; OTTMUSP00000008143; p14; p14ARF; p16; p16-INK4; p16-INK4a; p16(INK4a); p16I; p16INK4; P16ink4a; p16INK4A; p19; p19; p19ARF; p19Arf; Pct; Pctr1; TP16