PDX1 Antibodies

Target Information

Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell. Belongs to the Antp homeobox family. IPF1/XlHbox-8 subfamily. Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells). Note: This description may include information from UniProtKB.

Alternate Names

Glucose-sensitive factor; GSF; IDX-; IDX-1; Insulin promoter factor 1; insulin promoter factor 1, homeodomain transcription factor; Insulin upstream factor 1; IPF; IPF-1; IPF1; Ipf1; Islet/duodenum homeobox 1; Islet/duodenum homeobox-1; IUF-1; IUF1; Mody; MODY4; Mody4; PAGEN1; Pancreas/duodenum homeobox protein 1; pancreatic and duodenal homeobox 1; pancreatic and duodenal homeobox gene 1; pancreatic-duodenal homeobox factor 1; pdx-; PDX-1; pdx-1; PDX1; Pdx1; somatostatin transcription factor 1; Somatostatin-transactivating factor 1; STF-; STF-1; STF1