PTBP2 Antibodies

Target Information

RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA. Mainly expressed in brain although also detected in other tissues like heart and skeletal muscle. Isoform 1 and isoform 2 are specifically expressed in neuronal tissues. Isoform 3 and isoform 4 are expressed in non-neuronal tissues. Isoform 5 and isoform 6 are truncated forms expressed in non-neuronal tissues. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

brPTB; FLJ34897; neural polypyrimidine tract binding protein; Neural polypyrimidine tract-binding protein; Neurally-enriched homolog of PTB; NPTB; nPTB5; nPTB6; nPTB7; nPTB8; polypyrimidine tract binding protein 2; Polypyrimidine tract-binding protein 2; PTB; PTB-like protein; PTBLP; PTBP2; splicing regulator