REG4 Antibodies

Target Information

Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium. Highly expressed in the gastrointestinal tract including the duodenum, jejunum, ileum, ileocecum, appendix, descending colon, pancreas and small intestine. Weakly expressed in normal colon and stomach. Strongly expressed in most colorectal tumors than in normal colon. Preferentially expressed in mucinous tumors and in some cases neuro-endocrine tumors. Expressed in mucus-secreting cells and enterocyte-like cells. In small intestine expressed at the basal perinuclear zone of goblet cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

2010002L15Rik; Gastrointestinal secretory protein; GISP; Reg IV; REG-4; REG-IV; REG-like protein; REG4; Reg4; regenerating family member 4; regenerating gene type IV; regenerating islet-derived family, member 4; Regenerating islet-derived protein 4; Regenerating islet-derived protein IV; RELP