SCN10A Antibodies

Target Information

Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms. Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily. Expressed in the dorsal root ganglia and sciatic nerve. Note: This description may include information from UniProtKB.

Alternate Names

FEPS2; hPN3; Nav1.8; Peripheral nerve sodium channel 3; PN3; SCN10A; SCNAA; SNS; Sodium channel protein type 10 subunit alpha; Sodium channel protein type X subunit alpha; sodium channel, voltage-gated, type X, alpha polypeptide; sodium channel, voltage-gated, type X, alpha subunit; sodium voltage-gated channel alpha subunit 10; Voltage-gated sodium channel subunit alpha Nav1.8