SETD1B Antibodies

Target Information

Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro. Belongs to the class V-like SAM-binding methyltransferase superfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

FLJ20803; Histone-lysine N-methyltransferase SETD1B; hSET1B; IDDSELD; KIAA1076; KMT2G; Lysine N-methyltransferase 2G; SET domain containing 1B; SET domain containing 1B, histone lysine methyltransferase; SET domain-containing protein 1B; SET1B; SETD1B