SHP-1 Antibodies

Target Information

Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis. Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily. Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

HCP; HCPH; hematopoietic cell phosphatase; Hematopoietic cell protein-tyrosine phosphatase; HPTP1C; protein tyrosine phosphatase non-receptor type 6; protein tyrosine phosphatase, non-receptor type 6; Protein-tyrosine phosphatase 1C; Protein-tyrosine phosphatase SHP-1; PTN6; PTP-1C; PTP1C; PTPN6; SH-PTP1; SHP-1; SHP-1L; SHP1; Tyrosine-protein phosphatase non-receptor type 6