SMAD2 Antibodies

Target Information

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. Belongs to the dwarfin/SMAD family. Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Alternate Names

7120426M23Rik; hMAD-2; hSMAD2; JV18; JV18-1; Mad; MAD homolog 2; MAD homolog 2 (Drosophila); Mad protein homolog; Mad-related protein 2; MAD, mothers against decapentaplegic homolog 2; Madh; MADH2; Madh2; MADR2; Madr2; MGC22139; MGC34440; mMad2; mother against DPP homolog 2; Mothers against decapentaplegic homolog 2; Mothers against DPP homolog 2; Sma- and Mad-related protein 2; SMAD 2; SMAD family member 2; Smad-2; SMAD, mothers against DPP homolog 2; SMAD2; Smad2