TMEM119 Antibodies
Target Information
Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts. May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Upregulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation. Expressed in brain microglia (at protein level). Elevated expression levels seen in the brain of patients with Alzheimer disease. Expressed by osteoblast-like cells in bone tissues and follicular dendritic cells in lymphoid tissues. Note: This description may include information from UniProtKB.
Alternate Names
AW208946; BC025600; MGC38046; OBIF; obif; Osteoblast induction factor; TM119; TMEM119; Tmem119; Transmembrane protein 119TMEM119 Antibody Products
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